SPCRN



Studies Open to Recruitment 2011-12

If you would like further information about any of the studies below, pleaase email Jill Sutherland, SPCRN Database & Research Administrator.

Study Title Chief Investigator Funder Recruitment

The Scottish Family Health Study (Generation Scotland)

Professor Andrew Morris, University of Dundee

Scottish Government Health Directorate

East & West

PATHWAY 1: Monotherapy vs Dual Therapy for Initial Treatment for Hypertension.

Professor Morris Brown, University of Cambridge

BHF

East, South East & West

PATHWAY 2: Prevention and treatment of hypertension with algorithm based therapy (Pathway) Number 2. A multicentre Phase 4 study of optimal treatment of drug resistant hypertension.

Professor Morris Brown, University of Cambridge

BHF

East, South East & West

PATHWAY 3: A multicentre phase 4 study of comparison of single and combination diuretics in low-rennin hypertension.

Professor Morris Brown, Univesity of Cambridge

BHF

East, South East & West

Interstroke: Importance of conventional and emerging risk factors for stroke in different regions of the world and in different ethnic groups: a case controlled study.

Professor Peter Langhorne, University of Glasgow

Chest Heart & Stroke Scotland

North East & West

LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results. A five year Multi-centre, International, Randomised Double-blind, Placebo-controlled Trial to Determine Liraglutide Effects on Cardiovascular Events (COMMERCIAL).

Professor Stephen Bain, University of Swansea

Novo Nordisk

North East & West

TECOS: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes after Treatment with Sitagliptin in Patients with Type 2 Diabetes Mellitus and Inadequate Glycemic Control on Mono- or Dual Combination Oral Antihyperglycemic Therapy (COMMERCIAL).

Professor Rury Holman, University of Oxford

Merck & Co Inc

North East & West

The impact of a telemetric monitoring service in type 2 Diabetes: randomised controlled trial with nested qualitative study.

Dr Brian McKinstry, University of Edinburgh

Chief Scientist Office

North & South East

SEARCH Breast Cancer - A Population based study of genetic predisposition and gene-environment interactions in breast cancer.

Dr Paul Pharoah, Cambridge

Cancer Research UK

North, North East, West, South East & East

SEARCH Endometrial Cancer - A Population based study of genetic predisposition and gene-environment interactions in endometrial cancer.

Dr Paul Pharoah, Cambridge

Cancer Research UK

North, North East, West, South East & East

SEARCH Other Cancers - A Population based study of genetic predisposition and gene-environment interactions in cancer.

Dr Paul Pharoah, Cambridge

Cancer Research UK

North, North East, West, South East & East

SEARCH Ovarian Cancer - A Population based study of genetic predisposition and gene-environment interactions in ovarian cancer.

Dr Paul Pharoah, Cambridge

Cancer Research UK

North, North East, West, South East & East

PAGES - Establishing a database to study gene-environment interactions and pharmacogenomics for asthma among Scottish children.

Dr Steve Turner, University of Aberdeen

CSO

North & North East

IQuAD Imrpoving the Quality of Dentistry: A randomised controlled trial comparing oral hygieve advice and peridontal instrumentation for the prevention and management of peridontal disease in dentate adults attending dental primary care.

Professor Jan Clarkson, Dental Health Services and Research Unit, Dundee

HTA

North, North East, West, South East & East

Maximising physical function in later life: a 2-centre randomised controlled trial of progressive resistance exercise training in combination with ACE inhibition.

Professor Marion McMurdo, University of Dundee

CSO

East

TRACE RA: Trial of atorvastatin for the primary prevention of cardiovascular events in rheumatoid arthritis.

Professor George Kitas, Dudley Group of Hospitals NHS Trust

Arthritis Research Campaign

East

GenCep: A pilot investigation into the feasibility of developing a record-linked database to study the genetics of childhood eczema in primary care

Prof Frank Sullivan, University of Dundee

CSO

East

3P Study - Do phosphodiesterase 5 inhibitors improve exercise capacity in COPD patients with pulmonary hypertension?

Professor Allan Struthers, Ninewells Hospital, Dundee

CSO

East

The TASCFORCE Project: Tayside Screening for risk of cardiac events.

Professor Jill Belch, University of Dundee

Chest Heart & Stroke Scotland

East

BIOSTAT-Tayside CHF: A system BIOlogy Study to TAilored Treatment: Tayside Comprehensive Heart Funtion Study

Professor C C Lang, University of Dundee

EC Seventhg Framework Programme (FP7) Co-operation-Health

East

PROVIDE : Effect of nutritional supplementation on physical performance in elderly (COMMERCIAL)

Professor Marion McMurdo, University of Dundee

Danone Research

East

KIMVASC: Vitamin K to improve markers of vascular health and physical function in older patients with vascular disease - a randomised controlled trial

Dr Miles Witham, University of Dundee

Chest Heart & Stroke Scotland

East

DUAL/IDegLira: A trial comparing the efficacy and safety of insulin degludec/liraglutide, insulin degludec and liraglutide in subjects with type 2 diabetes (COMMERCIAL)

Ms Claire Henderson, Fife

Novo Nordisk

East

Identifying older heart failure patients with depression in primary care: a pilor study

Professor Marion McMurdo, University of Dundee

CSO

East

Exploring reasons for engagement with Hearty Lives Dundee.

Miss Ruth Dryden, SDHI, University of Dundee

BHF

East

LANSCAPE-Comparison of a basal plus one insulin regimen (glargine/glulisine) with a biphasic insulin regimen (NovoMix 30) in type 2 patients after basal insulin optimisation (COMMERCIAL).

Professor Jiten Vora, Royal Liverpool University Hospital

Sanofi Aventis

North East

Epidemiology, prevalence and characteristics of heart failure with preserved left ventricular ejection fraction.

Prof Michael Frenneaux, School of Medicine and Dentistry, University of Aberdeen

BHF

North East

WAIT - Parent-determined oral montelukast therapy for preschool wheeze

Prof Jonathon Grigg, Queen Mary Uni London/Barts and the London School of Medicine

NIHR/MRC Efficacy and Mechanism Evaluation programme

North East

5 alpha Reductase Inhibitors and Metabolism Study (RIMS).

Professor Brian Walker, University of Edinburgh

CSO

South East

PROactive ( part 2). Physical Activity as a crucial Patient Reported Outcome in Chronic Obstructive Pulmonary Disease (COPD)

CSO

South East

South Asian Carotid Plaques - A novel assessment of vascular disease, and its association with insulin resistance and adiposity in South Asians.

Professor Naveed Sattar, University of Glasgow

CHSS

West

Getting out of the House Study: A multi-centre randomised controlled trial of rehabilitation aimed at improving outdoor mobility for people who have had a stroke (TOMAS)

Dr Pip Logan, University of Nottingham

HTA

West

Patient/carer/clinician experience of palliative care in heart failure.

Professor Frances Mair, University of Glasgow

BHF

West

Developing a conceptual model of the burden of treatment and the work involved in living with heart failure.

Professor Frances Mair, University of Glasgow

CSO

West


Scottish School of Primary Care